Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability.

Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability.

Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is reduced in COPD-derived lung fibroblasts. The AhR also suppresses COX-2 in resp...

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Bibliographic Details
Main Authors: Michela Zago, Jared A Sheridan, Hussein Traboulsi, Emelia Hecht, Yelu Zhang, Necola Guerrina, Jason Matthews, Parameswaran Nair, David H Eidelman, Qutayba Hamid, Carolyn J Baglole
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5531650?pdf=render

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http://europepmc.org/articles/PMC5531650?pdf=render

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