Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb

Macrophage M2 polarization induced by exosomes from adipose-derived stem cells contributes to the exosomal proangiogenic effect on mouse ischemic hindlimb

Abstract Background M2 macrophages and exosomes from adipose-derived stem cells (ASCs) are both reported to promote angiogenesis. However, the possible synergistic effects between exogenous exosomes and endogenous M2 macrophages are poorly understood. Methods Exosomes were isolated from conditioned...

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Bibliographic Details
Main Authors: Dihan Zhu, Takerra K. Johnson, Yang Wang, Miracle Thomas, Ky Huynh, Qinglin Yang, Vincent C. Bond, Y. Eugene Chen, Dong Liu
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
Exosome
Stem cells
Macrophage
Angiogenesis
microRNA
Online Access:http://link.springer.com/article/10.1186/s13287-020-01669-9

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