Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis

Pien-Tze-Huang prevents hepatocellular carcinoma by inducing ferroptosis via inhibiting SLC7A11-GSH-GPX4 axis

Abstract Background Malignant transformation from hepatic fibrosis to carcinogenesis may be a therapeutic target for hepatocellular carcinoma (HCC). The aim of this study was to evaluate anti-cancer efficacy of Pien-Tze-Huang (PZH), and to investigate the underlying mechanisms by integrating transcr...

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Bibliographic Details
Main Authors: Xiangying Yan, Yudong Liu, Congchong Li, Xia Mao, Tengteng Xu, Zhixing Hu, Chu Zhang, Na Lin, Ya Lin, Yanqiong Zhang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cancer Cell International
Subjects:
Hepatocellular carcinoma
Pien-Tze-Huang
Ferroptosis
Solute carrier family 7 member 11
Glutathione
Glutathione peroxidase 4
Online Access:https://doi.org/10.1186/s12935-023-02946-2

Internet

https://doi.org/10.1186/s12935-023-02946-2

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