Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo

Specific Jak3 Downregulation in Lymphocytes Impairs γc Cytokine Signal Transduction and Alleviates Antigen-driven Inflammation In Vivo

Jak3, one of the four members comprising the Jak family of cytosolic tyrosine kinases, has emerged as a promising target for nontoxic immunotherapies. Although a number of Jak inhibitors has already demonstrated efficacy, they suffer from secondary effects apparently associated to their pan-Jak acti...

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Bibliographic Details
Main Authors: Alicia G Gómez-Valadés, María Llamas, Sílvia Blanch, José C Perales, Juan Román, Lluís Gómez-Casajús, Cristina Mascaró
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
cytokines
inflammation
RNA interference
T-lymphocyte
therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301019

Internet

http://www.sciencedirect.com/science/article/pii/S2162253116301019

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