Lifespan and healthspan benefits of exogenous H2S in C. elegans are independent from effects downstream of eat-2 mutation

Abstract Caloric restriction (CR) is one of the most effective interventions to prolong lifespan and promote health. Recently, it has been suggested that hydrogen sulfide (H2S) may play a pivotal role in mediating some of these CR-associated benefits. While toxic at high concentrations, H2S at lower...

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Bibliographic Details
Main Authors: Li Theng Ng, Li Fang Ng, Richard Ming Yi Tang, Diogo Barardo, Barry Halliwell, Philip Keith Moore, Jan Gruber
Format: Article
Language:English
Published: Nature Portfolio 2020-06-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-020-0044-8