Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats

Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats

Background. The product combination of Piper crocatum Ruiz. and Pav., Phyllanthus niruri Linn., and Typhonium flagelliforme (Lodd.) BL ethanolic extract (SKM) exerts immunomodulatory activity. However, the toxicity profile of the combination has never been investigated. Objective. This study aimed t...

Full description

Bibliographic Details
Main Authors:	Retno Murwanti, A. Nurrochmad, Andayana P. Gani, Ediati Sasmito, Angela E. Edwina, Mayang K. Chandra, F. H. Suryawan, A. R. Wardana, null Natalia, Jelita L. S. R. Budiningsih
Format:	Article
Language:	English
Published:	Hindawi Limited 2023-01-01
Series:	Journal of Toxicology
Online Access:	http://dx.doi.org/10.1155/2023/7511397

Similar Items

AKTIVITAS IMUNOSTIMULATOR KOMBINASI EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L.), UMBI KELADI TIKUS (Typhonium flagelliforme (Lodd.) Blume) DAN DAUN SIRIH MERAH (Piper crocatum Ruiz and Pav) TERHADAP FAGOSITOSIS MAKROFAG MENCIT JANTAN GALUR Balb/c
by: , VANIA, et al.
Published: (2014)

UJI AKTIVITAS FAGOSITOSIS MAKROFAG KOMBINASI EKSTRAK ETANOL HERBA MENIRAN (Phyllanthus niruri L.), DAUN SIRIH MERAH (Piper crocatum Ruiz. & Pav.), DAN UMBI KELADI TIKUS (Typhonium flagelliforme (Lodd.) Blume) SECARA IN VITRO
by: , LISTYA DIFITA, et al.
Published: (2014)

Antibacterial and antioxidant activities of Typhonium flagelliforme (Lodd.) Blume tuber
by: Mohan, Syam, et al.
Published: (2008)

Investigations of antioxidant and antibacterial activities of Typhonium flagelliforme (Lodd.) Blume leaves.
by: Mohan, Syam, et al.
Published: (2008)

Cytotoxicity assay of Typhonium flagelliforme Lodd against breast and cervical cancer cells
by: Endang Purwaningsih, et al.
Published: (2014-08-01)

Cytotoxicity assay of Typhonium flagelliforme Lodd against breast and cervical cancer cells
by: Etty Widayanti, et al.
Published: (2014-08-01)

AKTIVITAS IMUNOSTIMULAN KOMBINASI EKSTRAK ETANOLIK UMBI KELADI TIKUS (Typhonium flagelliforme (Lodd.) Blume), HERBA MENIRAN (Phyllantus niruri Linn.), DAN DAUN SIRIH MERAH (Piper crocatum) TERHADAP PROLIFERASI LIMFOSIT PADA MENCIT Balb/c YANG DIINDUKSI VAKSIN HEPATITIS B
by: , NOVITA NUR DIARINI, et al.
Published: (2014)

In Vitro Anticancer Activity Guided Investigation Of The Phytochemicals Of Typhonium Flagelliforme (Lodd.) Blume (Araceae)
by: Lai , Choon Sheen
Published: (2010)

PENGEMBANGAN TANAMAN KELADI TIKUS (TYPHONIUM FLAGELLIFORME LODD.) ASAL INDONESIA SEBAGAI OBAT ANTIKANKER
by: Nesti Fronika Sianipar, et al.
Published: (2016-01-01)

Preclinical anticancer activity of Typhonium flagelliforme (Lodd.) Blume and its potential mechanism: A systematic review
by: Kwok Wen Ng, et al.
Published: (2023-10-01)

The Effects of Gamma Irradiation on Growth Response of Rodent Tuber (Typhonium flagelliforme Lodd.) Mutant in In Vitro Culture
by: NESTI FRONIKA SIANIPAR, et al.
Published: (2013-06-01)

Genetic Variation of the First Generation of Rodent Tuber (Typhonium flagelliforme Lodd.) Mutants Based on RAPD Molecular Markers
by: NESTI FRONIKA SIANIPAR, et al.
Published: (2015-04-01)

Acute Toxicity of Keladi Tikus (Typhonium flagelliforme (Lodd.) Blume) Ethanol Extract on Zebrafish (Danio rerio) Embryo In Vivo
by: Fajar Fakri, et al.
Published: (2020-12-01)

The inhibition of Typhonium flagelliforme Lodd. Blume leaf extract on COX-2 expression of WiDr colon cancer cells
by: Agustina Setiawati, et al.
Published: (2016-03-01)

Pengaruh intensitas cahaya dan cekaman air terhadap kandungan Alkaloid pada Keladi Tikus [Typhonium flagelliforme (Lodd.) Bl.]
by: , SULISTYONO, et al.
Published: (2004)

Extracts of Typhonium flagelliforme tubers for treatment of leukemia.
by: Abdul, Ahmad Bustamam, et al.
Published: (2010)

Analysis of preliminary phytochemical screening of Typhonium flagelliforme
by: Galehpardsari, Motahareh Nobakht, et al.
Published: (2010)

UJI IMUNOMODULATOR KOMBINASI EKSTRAK ETANOLIK HERBA MENIRAN (Phyllantus niruri Linn.), UMBI KELADI TIKUS (Thyphonium flagelliforme)(Lodd.) Blume, DAN DAUN SIRIH MERAH (Piper crocatum)TERHADAP FAGOSITOSIS MAKROFAG SECARA IN VITRO
by: , REYNELDA JULIANI SAGALA, et al.
Published: (2014)

Potensi Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme Lodd.) Sebagai Induktor Apoptosis Sel Kanker Lidah Manusia (SP-C1)
by: Himmaturojuli Rosyid Ridlo, et al.
Published: (2012-07-01)

Typhonium flagelliforme decreases protein expression in murine breast cancer
by: Chodidjah Chodidjah, et al.
Published: (2014-12-01)

The growth of Typhonium flagelliforme treated with different levels of thidiazuron and N⁶ benzylaminopurine
by: Sunoto @ Hj. Faisal, Vajidah
Published: (2012)

In vitro mass propagation of Typhonium flagelliforme as affected by plant growth regulators
by: Galehpardsari, Motahareh Nobakht, et al.
Published: (2009)

Typhonium flagelliforme decreases tyrosine kinase and Ki67 expression in mice
by: Chodidjah Chodidjah, et al.
Published: (2015-12-01)

Effects of organic and inorganic fertilizers on the growth and yield of rodent tuber (Typhonium flagelliforme)
by: Mat Napi, Mohamad Faiz
Published: (2015)

The cytotoxic effect of typhonium flagelliforme and clinacanthus mutans on breast cancer cell line /
by: Nadhira Atiqah Khiru Nasir, 1989- , author, et al.
Published: (2015)

In Vitro Mass Propagation, Anti-Cancer Activity and Phytochemical Analysis of Typhonium Flagelliforme
by: Galehpardsari, Motahareh Nobakht
Published: (2009)

The cytotoxic effect of typhonium flagelliforme and clinacanthus nutans on breast cancer cell line
by: Khiru Nasir, Nadhira Atiqah
Published: (2015)

Anticancerous efect of Typhonium flagelliforme on human T4-lymphoblastoid cell line CEM-ss
by: Mohan, Syam, et al.
Published: (2008)

Anticancer Effect of a Typhonium flagelliforme L. in Raji Cells Through Telomerase Expression
by: Endang Purwaningsih, et al.
Published: (2017-04-01)

The cytotoxic effect of typhonium flagelliforme and clinacanthus mutans on breast cancer cell line [electronic resource] /
by: Nadhira Atiqah Khiru Nasir, 1989- , author
Published: (2015)

Nutritional Composition, Antioxidant Activity And Anticarcinogenic Effect Of Typhonium Flagelliforme (Nicholson 1029) Extract In Rat
by: Karuppiah, Thilakavathy
Published: (2000)

The effects of different strength of MS media in solid and liquid media on in vitro growth of Typhonium flagelliforme
by: Nur Inani Rezali, et al.
Published: (2017-02-01)

Typhonium flagelliforme inhibits the proliferation of murine leukemia WEHI-3 cells in vitro and induces apoptosis in vivo
by: Mohan, Syam, et al.
Published: (2010)

Antimicrobial and cytotoxic activities of endophytic fungi isolated from Piper crocatum Ruiz & Pav
by: Puji Astuti, et al.
Published: (2014-07-01)

Characterisation of Two Photosensitizing Compounds from Typhonium Flagelliforme Schott and Their Mode of Action in Inducing Cancer Cell Death
by: Ho, Anthony Siong Hock
Published: (2002)

Anti-Leukemic Effects of Typhonium Flagelliforme on Human Lymphoblastoid Cells (CEMss) and Murine Leukemic (WEHI-3) Model
by: Syam Mohan, Murali Mohan
Published: (2010)

In vitro ultramorphological assessment of apoptosis on CEMss induce by linoleic acid-rich fraction form Typhonium flagelliforme tuber.
by: Mohan, Syam Murali, et al.
Published: (2010)

Mutant Plant Tipobio Variety of Rodent Tuber (Typhonium Flagelliforme): Fatty Acids Compounds and in Vitro Anticancer Activity
by: Sianipar Nesti Fronika, et al.
Published: (2023-01-01)

An updated review of Typhonium flagelliforme: phytochemical compound, pharmacological activities and the use of vitexin and isovitexin as flavonoid compound in cosmetics development
by: Hetty Lendora Maha, et al.
Published: (2023-08-01)

Potential Ekstract Of Red Betel Leaf (Piper crocatum Ruiz & Pav.) as a Natural Hand Sanitizer
by: Maya Monica Manurung, et al.
Published: (2023-08-01)