The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses

The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses

BackgroundEquine metabolic syndrome (EMS) is a multifactorial pathology gathering insulin resistance, low-grade inflammation and past or chronic laminitis. Among the several molecular mechanisms underlying EMS pathogenesis, increased negative insulin signalling regulation mediated by protein tyrosin...

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Bibliographic Details
Main Authors: Lynda Bourebaba, Anna Serwotka-Suszczak, Ariadna Pielok, Mateusz Sikora, Malwina Mularczyk, Krzysztof Marycz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
EMS
PTP1B
MSI-1436
liver metabolism
autophagy
insulin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1149610/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1149610/full

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