Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression

Downregulation of IRF8 in alveolar macrophages by G-CSF promotes metastatic tumor progression

Summary: Tissue-resident macrophages (TRMs) are abundant immune cells within pre-metastatic sites, yet their functional contributions to metastasis remain incompletely understood. Here, we show that alveolar macrophages (AMs), the main TRMs of the lung, are susceptible to downregulation of the immun...

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Bibliographic Details
Main Authors: Stephanie L. Tzetzo, Elliot D. Kramer, Hemn Mohammadpour, Minhyung Kim, Spencer R. Rosario, Han Yu, Melissa R. Dolan, Chetan C. Oturkar, Brian G. Morreale, Paul N. Bogner, Aimee B. Stablewski, Fernando J. Benavides, Craig M. Brackett, John M.L. Ebos, Gokul M. Das, Mateusz Opyrchal, Michael J. Nemeth, Sharon S. Evans, Scott I. Abrams
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:iScience
Subjects:
Microenvironment
Immunology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224004085

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http://www.sciencedirect.com/science/article/pii/S2589004224004085

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