MCM7 supports the stemness of bladder cancer stem-like cells by enhancing autophagic flux

Summary: Autophagy plays critical roles in the pluripotent stemness of cancer stem cells (CSCs). However, how CSCs maintain the elevated autophagy to support stemness remains elusive. Here, we demonstrate that bladder cancer stem-like cells (BCSLCs) are at slow-cycling state with enhanced autophagy...

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Bibliographic Details
Main Authors: Lijun Mo, Bijia Su, Lili Xu, Zhiming Hu, Hongwei Li, Hongyan Du, Jinlong Li
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222013013