Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids

Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids

We have synthesized a small series of five 3-[4-arylmethoxy)phenyl]propanoic acids employing an easy and short synthetic pathway. The compounds were tested in vitro against a set of four protein targets identified as key elements in diabetes: G protein-coupled receptor 40 (GPR40), aldose reductase (...

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Bibliographic Details
Main Authors: Blanca Colín-Lozano, Samuel Estrada-Soto, Fabiola Chávez-Silva, Abraham Gutiérrez-Hernández, Litzia Cerón-Romero, Abraham Giacoman-Martínez, Julio Cesar Almanza-Pérez, Emanuel Hernández-Núñez, Zhilong Wang, Xin Xie, Mario Cappiello, Francesco Balestri, Umberto Mura, Gabriel Navarrete-Vazquez
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
diabetes
GPR40
AKRB1
PPARγ, GLUT-4
Online Access:http://www.mdpi.com/1420-3049/23/2/340

Internet

http://www.mdpi.com/1420-3049/23/2/340

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