Impact of <i>ABCG2</i> and <i>ABCB1</i> Polymorphisms on Imatinib Plasmatic Exposure: An Original Work and Meta-Analysis

Impact of <i>ABCG2</i> and <i>ABCB1</i> Polymorphisms on Imatinib Plasmatic Exposure: An Original Work and Meta-Analysis

Adequate imatinib plasma levels are necessary to guarantee an efficacious and safe treatment in gastrointestinal stromal tumor (GIST) and chronic myeloid leukemia (CML) patients. Imatinib is a substrate of the drug transporters ATP-binding cassette subfamily B member 1 (ABCB1) and ATP-binding casset...

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Bibliographic Details
Main Authors: Chiara Dalle Fratte, Jerry Polesel, Sara Gagno, Bianca Posocco, Elena De Mattia, Rossana Roncato, Marco Orleni, Fabio Puglisi, Michela Guardascione, Angela Buonadonna, Giuseppe Toffoli, Erika Cecchin
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:International Journal of Molecular Sciences
Subjects:
imatinib mesylate
ABCB1
ABCG2
pharmacogenetics
therapeutic drug monitoring
GIST
Online Access:https://www.mdpi.com/1422-0067/24/4/3303

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https://www.mdpi.com/1422-0067/24/4/3303

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