Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis

Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis

BACKGROUND Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infec...

Full description

Bibliographic Details
Main Authors: Nallely Lopez-Lopez, Ana Gabriela Ramos Martinez, Mariana Haydee Garcia-Hernandez, Rogelio Hernandez-Pando, Julio Enrique Castañeda-Delgado, Geanncarlo Lugo-Villarino, Céline Cougoule, Olivier Neyrolles, Bruno Rivas-Santiago, Monica Alejandra Valtierra-Alvarado, Marisela Rubio-Caceres, Jose Antonio Enciso-Moreno, Carmen Judith Serrano
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2018-02-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
diabetes
tuberculosis
virulence
macrophages
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000400304&lng=en&tlng=en

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762018000400304&lng=en&tlng=en

Similar Items