Efficacy of a small molecule inhibitor of the transcriptional cofactor PC4 in prevention and treatment of non-small cell lung cancer.

The human positive coactivator 4 (PC4) was originally identified as a multi-functional cofactor capable of mediating transcription activation by diverse gene- and tissue-specific activators. Recent studies suggest that PC4 might also function as a novel cancer biomarker and therapeutic target for di...

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Bibliographic Details
Main Authors: Yan Zhang, Andrei Pavlov, Sohail Malik, Hong Chen, Nancy Kim, Ziqing Li, Xiaohong Zhang, Melvin L DePamphilis, Robert G Roeder, Hui Ge
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0230670