Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Maintaining cellular redox homeostasis is critical for cell viability and growth, with disruptions implicated in cellular responses to chemicals and drugs. This study investigates the interactions between acylfulvenes (AFs), a class of DNA alkylating drugs, and thioredoxin (Trx), a key redox regulat...

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Bibliographic Details
Main Authors: Laura Slappendel, Xiaodan Liu, Michael R. Macarthur, Charles M. Sharpless, Shana J. Sturla
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-09-01
Series:Frontiers in Chemical Biology
Subjects:
drug metabolism
thioredoxin
acylfulvene
illudin S
protein alkylation
anticancer drug
Online Access:https://www.frontiersin.org/articles/10.3389/fchbi.2024.1462351/full

Internet

https://www.frontiersin.org/articles/10.3389/fchbi.2024.1462351/full

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