Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to determine the loss of intestinal Cdc42 upon inflam...

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Bibliographic Details
Main Authors: Dongsheng Zhang, Wenjuan Tang, Haitao Niu, William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Genes and Diseases
Subjects:
Cell division cycle 42 (CDC42)
Colitis
Colorectal cancer (CRC)
Inflammatory bowel diseases (IBD)
Intestinal epithelial cell (IEC)
Intestinal epithelial stem cell (IESC)
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304222003300

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http://www.sciencedirect.com/science/article/pii/S2352304222003300

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