BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells

BET bromodomain inhibition promotes neurogenesis while inhibiting gliogenesis in neural progenitor cells

Neural stem cells and progenitor cells (NPCs) are increasingly appreciated to hold great promise for regenerative medicine to treat CNS injuries and neurodegenerative diseases. However, evidence for effective stimulation of neuronal production from endogenous or transplanted NPCs for neuron replacem...

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Bibliographic Details
Main Authors: Jingjun Li, Jing Ma, Guofeng Meng, Hong Lin, Sharon Wu, Jamie Wang, Jie Luo, Xiaohong Xu, David Tough, Matthew Lindon, Inmaculada Rioja, Jing Zhao, Hongkang Mei, Rab Prinjha, Zhong Zhong
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Stem Cell Research
Subjects:
Neurogenesis
Gliogenesis
Neural progenitor cells
BET bromodomain
Small molecule inhibitor
I-BET
JQ-1
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506116300782

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http://www.sciencedirect.com/science/article/pii/S1873506116300782

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