Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein

Abstract GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear. Here, we employed cryo‐electron micros...

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Bibliographic Details
Main Authors: Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du
Format: Article
Language:English
Published: Wiley 2022-12-01
Series:MedComm
Subjects:
cryo‐EM
ECL2
GPCR
GPR17
protein structure
Online Access:https://doi.org/10.1002/mco2.159

Internet

https://doi.org/10.1002/mco2.159

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