Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein
Abstract GPR17 is a class A orphan G protein‐coupled receptor (GPCR) expressed in neurons and oligodendrocyte progenitors of the central nervous system (CNS). The signalling of GPR17 occurs through the heterotrimeric Gi, but its activation mechanism is unclear. Here, we employed cryo‐electron micros...
Main Authors: | Fang Ye, Thian‐Sze Wong, Geng Chen, Zhiyi Zhang, Binghao Zhang, Shiyi Gan, Wei Gao, Jiancheng Li, Zhangsong Wu, Xin Pan, Yang Du |
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Format: | Article |
Language: | English |
Published: |
Wiley
2022-12-01
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Series: | MedComm |
Subjects: | |
Online Access: | https://doi.org/10.1002/mco2.159 |
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