Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68

Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68

Derivatives of 3,4-hydroxypyridinones have been extensively studied for in vivo Fe3+ sequestration. Deferiprone, a 1,2-dimethyl-3,4-hydroxypyridinone, is now routinely used for clinical treatment of iron overload disease. Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe3+ at very low...

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Bibliographic Details
Main Authors: Ruslan Cusnir, Cinzia Imberti, Robert C. Hider, Philip J. Blower, Michelle T. Ma
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
hydroxypyridinone
deferiprone
gallium
iron overload
positron emission tomography
molecular imaging
bifunctional chelators
Online Access:http://www.mdpi.com/1422-0067/18/1/116

Internet

http://www.mdpi.com/1422-0067/18/1/116

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