Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models

Uncoupling p38α nuclear and cytoplasmic functions and identification of two p38α phosphorylation sites on β-catenin: implications for the Wnt signaling pathway in CRC models

Abstract Background Activation of the Wnt pathway has been linked to colorectal cancer (CRC). Previous reports suggest that Wnt3a can activate p38. Besides, p38α feeds into the canonical Wnt/β-catenin pathway by inhibiting GSK3β through phosphorylation. Recently, we identified p38α as a new druggabl...

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Bibliographic Details
Main Authors: Martina Lepore Signorile, Candida Fasano, Giovanna Forte, Katia De Marco, Paola Sanese, Vittoria Disciglio, Elisabetta Di Nicola, Antonino Pantaleo, Cristiano Simone, Valentina Grossi
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Cell & Bioscience
Subjects:
p38α
Wnt/β-catenin pathway
Colorectal cancer
Chromatin-associated kinase
Online Access:https://doi.org/10.1186/s13578-023-01175-4

Internet

https://doi.org/10.1186/s13578-023-01175-4

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