RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment

RER1 enhances carcinogenesis and stemness of pancreatic cancer under hypoxic environment

Abstract Background Increasing incidence and mortality rates of pancreatic cancer (PC) highlight an urgent need for novel and efficient drugs. Retention in endoplasmic reticulum 1 (RER1) is an important retention factor in the endoplasmic reticulum (ER). However, it remains elusive whether RER1 is i...

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Bibliographic Details
Main Authors: Shi Chen, Jiaqiang Zhang, Jiangzhi Chen, Yaodong Wang, Songqiang Zhou, Long Huang, Yannan Bai, Chenghong Peng, Baiyong Shen, Huixing Chen, Yifeng Tian
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic cancer (PC)
Retention in endoplasmic reticulum 1 (RER1)
Hypoxia
Stemness
Hypoxia-inducible factor (HIF)-1α
Online Access:http://link.springer.com/article/10.1186/s13046-018-0986-x

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http://link.springer.com/article/10.1186/s13046-018-0986-x

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