Molecular mechanism for direct actin force-sensing by α-catenin

The actin cytoskeleton mediates mechanical coupling between cells and their tissue microenvironments. The architecture and composition of actin networks are modulated by force; however, it is unclear how interactions between actin filaments (F-actin) and associated proteins are mechanically regulate...

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Bibliographic Details
Main Authors: Lin Mei, Santiago Espinosa de los Reyes, Matthew J Reynolds, Rachel Leicher, Shixin Liu, Gregory M Alushin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/62514