ICOS and OX40 tandem co-stimulation enhances CAR T-cell cytotoxicity and promotes T-cell persistence phenotype

ICOS and OX40 tandem co-stimulation enhances CAR T-cell cytotoxicity and promotes T-cell persistence phenotype

Chimeric Antigen Receptor (CAR) T-cell therapies have emerged as an effective and potentially curative immunotherapy for patients with relapsed or refractory malignancies. Treatment with CD19 CAR T-cells has shown unprecedented results in hematological malignancies, including heavily refractory leuk...

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Bibliographic Details
Main Authors: Eider Moreno-Cortes, Pedro Franco-Fuquen, Juan E. Garcia-Robledo, Jose Forero, Natalie Booth, Januario E. Castro
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Oncology
Subjects:
adoptive immunotherapy
chimeric antigen receptor
cell-and tissue-based therapy
T-cell activation
costimulatory molecules
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1200914/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1200914/full

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