SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

SeDeM tool-driven full factorial design for osmotic drug delivery of tramadol HCl: Formulation development, physicochemical evaluation, and in-silico PBPK modeling for predictive pharmacokinetic evaluation using GastroPlus™

The study is based on using SeDeM expert system in developing controlled-release tramadol HCl osmotic tablets and its in-silico physiologically based pharmacokinetic (PBPK) modeling for in-vivo pharmacokinetic evaluation. A Quality by Design (QbD) based approach in developing SeDEM-driven full facto...

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Bibliographic Details
Main Authors: Muhammad Talha Saleem, Muhammad Harris Shoaib, Rabia Ismail Yousuf, Farrukh Rafiq Ahmed, Kamran Ahmed, Fahad Siddiqui, Zafar Alam Mahmood, Muhammad Sikandar, Muhammad Suleman Imtiaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pharmacology
Subjects:
tramadol
SeDeM diagram expert system
PBPK
osmotic tablet
controlled release
gastroplus
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.974715/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.974715/full

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