Effects of LPS Composition in Escherichia coli on Antibacterial Activity and Bacterial Uptake of Antisense Peptide-PNA Conjugates

Effects of LPS Composition in Escherichia coli on Antibacterial Activity and Bacterial Uptake of Antisense Peptide-PNA Conjugates

The physical and chemical properties of the outer membrane of Gram-negative bacteria including Escherichia coli have a significant impact on the antibacterial activity and uptake of antibiotics, including antimicrobial peptides and antisense peptide-peptide nucleic acid (PNA) conjugates. Using a def...

Full description

Bibliographic Details
Main Authors: Lise Goltermann, Meiqin Zhang, Anna Elisabeth Ebbensgaard, Marija Fiodorovaite, Niloofar Yavari, Anders Løbner-Olesen, Peter E. Nielsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Microbiology
Subjects:
peptide nucleic acid (PNA)
antisense antimicrobials
bacterial uptake
cross-resistance
peptide antibiotics
lipopolysaccharide (LPS)
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.877377/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.877377/full

Similar Items