The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

We report data on the structural dynamics of the neuropeptide Y (NPY) G-protein-coupled receptor (GPCR) type 1 (Y1R), a typical representative of class A peptide ligand GPCRs, using a combination of solid-state NMR and molecular dynamics (MD) simulation. First, the equilibrium dynamics of Y1R were s...

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Bibliographic Details
Main Authors: Alexander Vogel, Mathias Bosse, Marcel Gauglitz, Sarah Wistuba, Peter Schmidt, Anette Kaiser, Vsevolod V. Gurevich, Annette G. Beck-Sickinger, Peter W. Hildebrand, Daniel Huster
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Molecules
Subjects:
GPCR
arrestin
molecular switch
NMR spectroscopy
structural dynamics
MD simulation
Online Access:https://www.mdpi.com/1420-3049/25/23/5489

Internet

https://www.mdpi.com/1420-3049/25/23/5489

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