Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritis

Abstract B cells play a significant role in established Rheumatoid Arthritis (RA). However, it is unclear to what extent differentiated B cells are present in joint tissue already at the onset of disease. Here, we studied synovial biopsies (n = 8) captured from untreated patients at time of diagnosi...

Full description

Bibliographic Details
Main Authors: Uta Hardt, Konstantin Carlberg, Erik af Klint, Peter Sahlström, Ludvig Larsson, Annika van Vollenhoven, Susana Hernandez Machado, Lena Israelsson, Khaled Amara, Karine Chemin, Marina Korotkova, Gunilla B. Karlsson Hedestam, Anca I. Catrina, Sarah A. Teichmann, Patrik L. Ståhl, Vivianne Malmström
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15293-5

Internet

https://doi.org/10.1038/s41598-022-15293-5

Similar Items