GITR/GITRL reverse signalling modulates the proliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylate ERK1/2 and Akt

GITR/GITRL reverse signalling modulates the proliferation of hepatic progenitor cells by recruiting ANXA2 to phosphorylate ERK1/2 and Akt

Abstract Hepatic stem/progenitor cells are the major cell compartment for tissue repair when hepatocyte proliferation is compromised in chronic liver diseases, but the expansion of these cells increases the risk of carcinogenesis. Therefore, it is essential to explore the pathways restricting their...

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Bibliographic Details
Main Authors: Yu He, Yufeng Pei, Kai Liu, Lin Liu, Yue Tian, Hongyi Li, Min Cong, Tianhui Liu, Hong Ma, Hong You, Jidong Jia, Dong Zhang, Ping Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04759-z

Internet

https://doi.org/10.1038/s41419-022-04759-z

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