Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis

Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis

Abstract Background Fibroblast-like synoviocytes (FLSs) from patients with rheumatoid arthritis (RA) are autonomously activated to maintain inflammation and joint destruction in co-transplantation models. To elucidate inducing mechanisms involved in this altered behavior, the arthritogenic potential...

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Bibliographic Details
Main Authors: Oliver Frey, Marion Hückel, Mieczyslaw Gajda, Peter K. Petrow, Rolf Bräuer
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Arthritis Research & Therapy
Subjects:
Arthritis
Synovial fibroblast
Joint destruction
Online Access:http://link.springer.com/article/10.1186/s13075-018-1720-y

Internet

http://link.springer.com/article/10.1186/s13075-018-1720-y

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