Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria

Parasitological profiling shows 4(1H)-quinolone derivatives as new lead candidates for malaria

4(1H)-quinolone is an attractive template for antimalarial drug discovery campaigns. Given the current global increase in drug and insecticide resistance, the discovery of new antimalarial drugs is an urgent goal for the fight against malaria. Here, the synthesis and antiplasmodial profiling of a se...

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Bibliographic Details
Main Authors: Juliana O. de Souza, Suzete M. Almeida, Guilherme E. Souza, Camila L. Zanini, Everton M. da Silva, Juliana Calit, Daniel Y. Bargieri, Kangsa Amporndanai, Svetlana Antonyuk, S. Samar Hasnain, Fabio C. Cruz, Dhelio B. Pereira, Glaucius Oliva, Arlene G. Corrêa, Anna C.C. Aguiar, Rafael V.C. Guido
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Malaria
Plasmodium falciparum
Plasmodium vivax
Inhibitor
4(1H)-Quinolone
Cytochrome bc1 complex
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417421000121

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http://www.sciencedirect.com/science/article/pii/S2772417421000121

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