Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation

Summary: Stress granules (SGs) constitute a signaling hub that plays a critical role in type I interferon responses. Here, we report that growth arrest and DNA damage-inducible beta (Gadd45β) act as a positive regulator of SG-mediated interferon signaling by targeting G3BP upon RNA virus infection....

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Main Authors: W.A. Gayan Chathuranga, Chamilani Nikapitiya, Jae-Hoon Kim, Kiramage Chathuranga, Asela Weerawardhana, Niranjan Dodantenna, Doo-Jin Kim, Haryoung Poo, Jae U. Jung, Chul-Ho Lee, Jong-Soo Lee
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723013700