In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes

Lactate, the end product of anaerobic glycolysis, is produced in high amounts by innate immune cells during inflammatory activation. Although immunomodulating effects of lactate have been reported, evidence from human studies is scarce. Here we show that expression of genes involved in lactate metab...

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Bibliographic Details
Main Authors: Jacqueline M. Ratter, Hanne M. M. Rooijackers, Guido J. Hooiveld, Anneke G. M. Hijmans, Bastiaan E. de Galan, Cees J. Tack, Rinke Stienstra
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
lactate
glycolysis
cytokines
immunometabolism
innate immune cells
monocytes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02564/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02564/full

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