Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1

Tryptophan Catabolism as Immune Mechanism of Primary Resistance to Anti-PD-1

Background: Clinical trials showed that only a subset of patients benefits from immunotherapy, suggesting the need to identify new predictive biomarker of resistance. Indoleamine-2,3-dioxygenase (IDO) has been proposed as a mechanism of resistance to anti-PD-1 treatment, and serum kynurenine/tryptop...

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Bibliographic Details
Main Authors: Andrea Botticelli, Silvia Mezi, Giulia Pomati, Bruna Cerbelli, Edoardo Cerbelli, Michela Roberto, Raffaele Giusti, Alessio Cortellini, Luana Lionetto, Simone Scagnoli, Ilaria Grazia Zizzari, Marianna Nuti, Maurizio Simmaco, Paolo Marchetti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
indoleamine-2,3-dioxygenase
tryptophan metabolism
tumor immunity
kynurenine
anti-PD-1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01243/full

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https://www.frontiersin.org/article/10.3389/fimmu.2020.01243/full

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