N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Abstract Hypoxic-ischemic brain damage (HIBD) can result in significant global rates of neonatal death or permanent neurological disability. N6-methyladenosine (m6A) modification of RNA influences fundamental aspects of RNA metabolism, and m6A dysregulation is implicated in various neurological dise...

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Bibliographic Details
Main Authors: Jianhui Deng, Yanling Liao, Jianghu Chen, Andi Chen, Shuyan Wu, Yongxin Huang, Haitao Qian, Fei Gao, Guixi Wu, Yisheng Chen, Xiaohui Chen, Xiaochun Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2023-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06343-5

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https://doi.org/10.1038/s41419-023-06343-5

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