Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Tongxinluo-pretreated mesenchymal stem cells facilitate cardiac repair via exosomal transfer of miR-146a-5p targeting IRAK1/NF-κB p65 pathway

Abstract Background Bone marrow cells (BMCs), especially mesenchymal stem cells (MSCs), have shown attractive application prospects in acute myocardial infarction (AMI). However, the weak efficacy becomes their main limitation in clinical translation. Based on the anti-inflammation and anti-apoptosi...

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Bibliographic Details
Main Authors: Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Myocardial infarction
Mesenchymal stem cells
Exosomes
Tongxinluo
Pretreatment
Online Access:https://doi.org/10.1186/s13287-022-02969-y

Internet

https://doi.org/10.1186/s13287-022-02969-y

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