Comparison of cisplatin-induced nephrotoxicity between single-dose and split-dose administration to rats

Comparison of cisplatin-induced nephrotoxicity between single-dose and split-dose administration to rats

To prevent cisplatin (CDDP)-induced nephrotoxicity, co-treatment with massive hydration is essential for its clinical use. However, some patients are ineligible for this treatment. For such patients, a split dose of CDDP has been suggested as an alternative strategy. This study aimed to evaluate the...

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Bibliographic Details
Main Authors: Keizo Fukushima, Azusa Futatsugi, Maiko Maekawa, Saya Naito, Akira Okada, Nobuyuki Sugioka
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cisplatin
Split dose
Fractionated administration
Acute kidney injury
Chronic kidney disease
Hydration
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222000075

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http://www.sciencedirect.com/science/article/pii/S0753332222000075

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