Molecular Modeling and simulation-based identification of inhibitors against new Delhi Metallo-Lactamase 1: Implications for bacterial antibiotic resistance

Molecular Modeling and simulation-based identification of inhibitors against new Delhi Metallo-Lactamase 1: Implications for bacterial antibiotic resistance

Objectives: Bacterial infections expressing New Delhi metallo-lactamase-1 (NDM-1) pose an escalating global threat to healthcare systems. NDM-1 is an enzyme that renders β-lactam antibiotics ineffective, leading to resistance against numerous antibiotics used in clinical practice. Therefore, there i...

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Bibliographic Details
Main Authors: Shafiul Haque, Darin Mansor Mathkor, Ayman K. Johargy, Hani Faidah, Ahmad O. Babalghith, Sumyya H. Hariri, Naif A. Jalal, Faraz Ahmad, Farkad Bantun
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Journal of King Saud University: Science
Subjects:
NDM-1
Vitas-M laboratory
Structure-based pharmacophore
Virtual screening
MM-GBSA
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364724002027

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http://www.sciencedirect.com/science/article/pii/S1018364724002027

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