The Complexity of the cGAS-STING Pathway in CNS Pathologies

The Complexity of the cGAS-STING Pathway in CNS Pathologies

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammatio...

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Bibliographic Details
Main Authors: Amelia L. Fryer, Amar Abdullah, Juliet M. Taylor, Peter J. Crack
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Neuroscience
Subjects:
STING
neuroinflammation
interferon
central nervous system
cGAS
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.621501/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.621501/full

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