Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

Aqueous Extract of Mori Folium Exerts Bone Protective Effect Through Regulation of Calcium and Redox Homeostasis via PTH/VDR/CaBP and AGEs/RAGE/Nox4/NF-κB Signaling in Diabetic Rats

Purpose: The present study is aimed to explore whether the aqueous extract of Mori Folium (MF) exhibits bone protective effect by regulating calcium and redox homeostasis in diabetic rats, and to identify the signaling pathways involved in this process.Methods: Diabetic rats were established using h...

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Bibliographic Details
Main Authors: Chenyue Liu, Ruyuan Zhu, Haixia Liu, Lin Li, Beibei Chen, Qiangqiang Jia, Lili Wang, Rufeng Ma, Simin Tian, Min Wang, Min Fu, Jianzhao Niu, Alexander N. Orekhov, Sihua Gao, Dongwei Zhang, Baosheng Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
Mori Folium
bone quality
diabetes
calcium homeostasis
redox equilibrium
PTH/VDR/CaBP
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01239/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01239/full

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