Xanthene derivatives increase glucose utilization through activation of LKB1-dependent AMP-activated protein kinase.

Xanthene derivatives increase glucose utilization through activation of LKB1-dependent AMP-activated protein kinase.

5' AMP-activated protein kinase (AMPK) is a highly conserved serine-threonine kinase that regulates energy expenditure by activating catabolic metabolism and suppressing anabolic pathways to increase cellular energy levels. Therefore AMPK activators are considered to be drug targets for treatme...

Full description

Bibliographic Details
Main Authors: Yonghoon Kwon, Parkyong Song, Jong Hyuk Yoon, Jaewang Ghim, Dayea Kim, Byungjun Kang, Taehoon G Lee, Jin-Ah Kim, Joong-Kwon Choi, In Kwon Youn, Hyeon-Kyu Lee, Sung Ho Ryu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4177559?pdf=render

Internet

http://europepmc.org/articles/PMC4177559?pdf=render

Similar Items