C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types

C9orf72 gene networks in the human brain correlate with cortical thickness in C9-FTD and implicate vulnerable cell types

IntroductionA hexanucleotide repeat expansion (HRE) intronic to chromosome 9 open reading frame 72 (C9orf72) is recognized as the most common genetic cause of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and ALS-FTD. Identifying genes that show similar regional co-expression p...

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Bibliographic Details
Main Authors: Iris J. Broce, Daniel W. Sirkis, Ryan M. Nillo, Luke W. Bonham, Suzee E. Lee, Bruce L. Miller, Patricia A. Castruita, Virginia E. Sturm, Leo S. Sugrue, Rahul S. Desikan, Jennifer S. Yokoyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Neuroscience
Subjects:
C9orf72
amyotrophic lateral sclerosis
frontotemporal dementia
imaging transcriptomics
gene networks
neurodegeneration
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2024.1258996/full

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https://www.frontiersin.org/articles/10.3389/fnins.2024.1258996/full

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