The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation

Abstract Background Oxygen therapy, using supraphysiological concentrations of oxygen (hyperoxia), is routinely administered to patients who require respiratory support including mechanical ventilation (MV). However, prolonged exposure to hyperoxia results in acute lung injury (ALI) and accumulation...

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Bibliographic Details
Main Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Sergio I. Valdés-Ferrer, Mosi Lin, Vivek Patel, Mao Wang, Ashley T. Martino, Jeanette C. Perron, Charles R. Ashby, Kevin J. Tracey, Valentin A. Pavlov, Lin L. Mantell
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Medicine
Subjects:
Hyperoxia
Lung injury
a7nAChR
Vagus nerve
Cholinergic anti-inflammatory pathway
Inflammatory reflex
Online Access:http://link.springer.com/article/10.1186/s10020-020-00177-z

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http://link.springer.com/article/10.1186/s10020-020-00177-z

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