Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

Selective transcriptomic dysregulation of metabolic pathways in liver and retina by short- and long-term dietary hyperglycemia

Summary: A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI diet to mice for 1 or 12 month. In the liver, genes associated with inflammation and...

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Bibliographic Details
Main Authors: Anupam K. Mondal, Daniel C. Brock, Sheldon Rowan, Zhi-Hong Yang, Krishna Vamsi Rojulpote, Kelsey M. Smith, Sarah G. Francisco, Eloy Bejarano, Milton A. English, Amy Deik, Sarah Jeanfavre, Clary B. Clish, Alan T. Remaley, Allen Taylor, Anand Swaroop
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Physiology
Metabolomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224002001

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http://www.sciencedirect.com/science/article/pii/S2589004224002001

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