Improving antibody optimization ability of generative adversarial network through large language model

Generative adversarial networks (GANs) have successfully generated functional protein sequences. However, traditional GANs often suffer from inherent randomness, resulting in a lower probability of obtaining desirable sequences. Due to the high cost of wet-lab experiments, the main goal of computer-...

Full description

Bibliographic Details
Main Authors: Wenbin Zhao, Xiaowei Luo, Fan Tong, Xiangwen Zheng, Jing Li, Guangyu Zhao, Dongsheng Zhao
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023004555