Macrophage MMP10 Regulates TLR7-Mediated Tolerance

Macrophage MMP10 Regulates TLR7-Mediated Tolerance

Using an in vivo model of tolerance to TLR7-induced skin inflammation, we found a critical role for macrophage-derived MMP10 in mediating immune hypo-responsiveness. Cutaneous exposure to Imiquimod (IMQ), a TLR7 agonist, induced acute expression of pro-inflammatory factors (IL1β, IL6, CXCL1) and neu...

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Bibliographic Details
Main Authors: Maryam G. Rohani, Elizabeth Dimitrova, Andrew Beppu, Ying Wang, Caroline A. Jefferies, William C. Parks
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
macrophage
tolerance
toll-like receptor
metalloproteinase
skin immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02817/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02817/full

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