The structural basis of the talin–KANK1 interaction that coordinates the actin and microtubule cytoskeletons at focal adhesions

Adhesion between cells and the extracellular matrix is mediated by heterodimeric (αβ) integrin receptors that are intracellularly linked to the contractile actomyosin machinery. One of the proteins that control this link is talin, which organizes cytosolic signalling proteins into discrete complexes...

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Bibliographic Details
Main Authors: Xingchen Li, Benjamin Thomas Goult, Christoph Ballestrem, Thomas Zacharchenko
Format: Article
Language:English
Published: The Royal Society 2023-06-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/10.1098/rsob.230058