Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence

Cancer immunotherapy with enveloped self-amplifying mRNA CARG-2020 that modulates IL-12, IL-17 and PD-L1 pathways to prevent tumor recurrence

Targeting multiple immune mechanisms may overcome therapy resistance and further improve cancer immunotherapy for humans. Here, we describe the application of virus-like vesicles (VLV) for delivery of three immunomodulators alone and in combination, as a promising approach for cancer immunotherapy....

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Bibliographic Details
Main Authors: Ju Chen, Bhaskara Reddy Madina, Elham Ahmadi, Timur Olegovich Yarovinsky, Marie Marthe Krady, Eileen Victoria Meehan, Isabella China Wang, Xiaoyang Ye, Elise Pitmon, Xian-Yong Ma, Bijan Almassian, Valerian Nakaar, Kepeng Wang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Virus-like vesicles
Oncolytic virus
IL-12
IL-17
PD-L1
T cell exhaustion
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523003416

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http://www.sciencedirect.com/science/article/pii/S2211383523003416

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