Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4+CD8+ T cells in ulcerative colitis

Epigenetic DNA methylation of Zbtb7b regulates the population of double-positive CD4+CD8+ T cells in ulcerative colitis

Abstract Background and aims Ulcerative colitis (UC) is a heterogeneous disorder with complex pathogenesis. Therefore, in the present study, we aimed to assess genome-wide DNA methylation changes associated explicitly with the pathogenesis of UC. Methods DNA methylation changes were identified by co...

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Bibliographic Details
Main Authors: Hao-ming Xu, Jing Xu, Mei-feng Yang, Yu-jie Liang, Quan-zhou Peng, Yuan Zhang, Cheng-mei Tian, Yu-qiang Nie, Li-sheng Wang, Jun Yao, De-feng Li
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Translational Medicine
Subjects:
Ulcerative colitis
Zbtb7b
DNA methylation
Colitis model
Online Access:https://doi.org/10.1186/s12967-022-03477-6

Internet

https://doi.org/10.1186/s12967-022-03477-6

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