Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and Dynamics

Viral polymerases replicate and transcribe the genomes of several viruses of global health concern such as Hepatitis C virus (HCV), human immunodeficiency virus (HIV) and Ebola virus. For this reason they are key targets for therapies to treat viral infections. Although there is little sequence simi...

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Bibliographic Details
Main Authors: Ester Sesmero, Ian F. Thorpe
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Viruses
Subjects:
Online Access:http://www.mdpi.com/1999-4915/7/7/2808