Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

Synaptotagmin-7 places dense-core vesicles at the cell membrane to promote Munc13-2- and Ca2+-dependent priming

Synaptotagmins confer calcium-dependence to the exocytosis of secretory vesicles, but how coexpressed synaptotagmins interact remains unclear. We find that synaptotagmin-1 and synaptotagmin-7 when present alone act as standalone fast and slow Ca2+-sensors for vesicle fusion in mouse chromaffin cells...

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Bibliographic Details
Main Authors: Bassam Tawfik, Joana S Martins, Sébastien Houy, Cordelia Imig, Paulo S Pinheiro, Sonja M Wojcik, Nils Brose, Benjamin H Cooper, Jakob Balslev Sørensen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
neurotransmitter release
chromaffin cell
SNARE-proteins
synaptotagmin-7
vesicle priming
capacitance measurements
Online Access:https://elifesciences.org/articles/64527

Internet

https://elifesciences.org/articles/64527

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